Despite the common belief that you must take ibuprofen with food, you can safely take low-dose ibuprofen (up to 1200 mg daily in divided doses for 1 to 7 days) on an empty stomach, and this provides faster pain relief than taking ibuprofen with food. Comment: Ibuprofen decreases the antiplatelet effects of low-dose aspirin by blocking the active site of platelet cyclooxygenase. Administer ibuprofen 8 h before aspirin or at least 2-4 h after. Adults can typically take 200 to 400 mg of ibuprofen every 4 to 6 hours, with a maximum of 3,200 mg per day. Taking more than the recommended amount may lead to serious side effects. Adults should not take more than 3,200 mg of ibuprofen in one day. For children, the maximum daily dose is 40 mg per kilogram of body weight. Ibuprofen and Tylenol can be used together to help with pain relief. Knowing the right ibuprofen dosage is key to managing pain safely. Detailed Ibuprofen dosage information for adults and children. Includes dosages for Pain, Osteoarthritis, Rheumatoid Arthritis and more; plus renal, liver and dialysis adjustments. Adults commonly take Ibuprofen in doses of 200 to 400 mg every 4 to 6 hours. Over-the-counter use should not exceed 1200 mg daily, but under medical supervision, doses up to 3200 mg per day may be prescribed. It’s best to take Ibuprofen with food or milk to reduce stomach irritation. Don’t take more than 1,200 milligrams of ibuprofen a day, unless directed by a provider. If you need it longer than 10 days, seek medical attention. GoodRx’s guide to ibuprofen dosages for adults includes information on the different forms of ibuprofen, dosage adjustments, and more. Ibuprofen (also known as Motrin and Advil) is a medicine used to reduce fever and pain. It is an over-the-counter medicine, meaning that you can get it without a doctor's prescription. This table can help you figure out the right amount to give. (Find a print-friendly version here.) Use your child's weight to decide on the right amount to give. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age—Use and dose must be determined by your doctor.